Protamine Based siRNA-Nanoparticles: Particle Composition Dependant Influences on RNA Interference Efficiency
نویسندگان
چکیده
منابع مشابه
Mutation of siRNA results in thermodynamically unstable duplex which influences knockdown of dmrt1 by RNA interference.
MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational repression and mRNA degradation. We report here that short interfering RNA (siRNA) mutation significantly changed kinetics of the folding and unfolding of secondary structures and decreased Tm value of the duplex melting. The mutant duplex was more unstable thermodynami...
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2010
ISSN: 0036-8709,2218-0532
DOI: 10.3797/scipharm.cespt.8.pnm16